Human health risks and hepatotoxicity associated with exposure to atrazine surveyed in drinking water from Ijebu-North, Southwest, Nigeria.

No recognized study has been conducted in rural agricultural areas in Nigeria to monitor atrazine in drinking water and its potential health implications. Here, a total of 69 hand-dug wells (HDW), 40 boreholes (BH), and 4 streams were collected from the six (6) communities in Ijebu-North Local Government Area, Southwest Nigeria and analyzed for atrazine residue using gas chromatography-mass spectrometry (GC-MS). Values of atrazine obtained were further used to evaluate the non-carcinogenic risk associated with ingestion and dermal routes in children and adults using the standard US EPA protocols. Sub-chronic hepatotoxicity of the atrazine residue in the water sample was assessed using standard methods. A total of 41 HDW, 22 BH, and the 4 streams tested positive for atrazine. The highest concentration of atrazine recorded in the HDW water from Ijebu-North ranged from 0.01 to 0.08 mg/L. Hazard index (HI) values associated with the exposure routes in both adults and children were less than 1 for all the communities. Although atrazine at 0.01, 0.03, and 0.04 mg/L concentrations appear to trigger defense mechanisms capable of protecting the structural integrity of the liver, significant (p < 0.05) changes in hepatic markers, oxidative stress parameters, mixed-function oxygenases, ATPase enzymes, and mild structural lesions were seen in the liver of rats exposed to atrazine at 0.08 mg/L. Atrazine at 0.01, 0.03, and 0.04 mg/L concentrations found in water from Ijebu-North may not pose any threat to liver function, but concern should be raised at 0.08 mg/L.