DNA methylation of the promoter region of bnip3 and bnip3l genes induced by metabolic programming.

Vincent VeronLucie MarandelJingwei LiuEmilio J VélezOlivier LepaisStéphane PanseratSandrine SkibaIban Seiliez

Published in: BMC genomics (2018)

Overall, these data demonstrate that methionine level and hypoxia stimulus can be of critical importance in metabolic programming. Both stimuli affected DNA methylation of specific loci, among them, an interesting CpG site have been identified, namely - 884 bp site of bnip3a, and may be positively related with mRNA levels.

Keyphrases

dna methylation
genome wide
gene expression
copy number
big data
binding protein
machine learning
transcription factor
bioinformatics analysis