Pathway-Affecting Single Nucleotide Polymorphisms (SNPs) in RPS6KA1 and MBIP Genes are Associated with Breast Cancer Risk.

Ghadah ShareefiAlaa Nabil TurkistaniAhmed AlsayyahHaitham Kussaibi Maha Abdel Hadi Khaled R Alkharsah

Published in: Asian Pacific journal of cancer prevention : APJCP (2020)

We showed that three, previously untested, SNPs are associated with increased risk of breast cancer in our population. This may be added to the list of factors involved in breast cancer risk assessment studies. The benefit and the utility of the in-silico prediction of disease risk factors and their genetic association had been demonstrated in this study, yet the predicted risk alleles have to be tested in clinical studies.<br />.

Keyphrases

breast cancer risk
genome wide
risk assessment
risk factors
dna methylation
copy number
heavy metals
gene expression
climate change
young adults
case control
genome wide identification