Cerebrospinal fluid proteomic profiling of individuals with mild cognitive impairment and suspected non-Alzheimer's disease pathophysiology.
Aurore DelvenneJohan GobomBetty TijmsIsabelle BosLianne M ReusValerija DobricicMara Ten KateFrans VerheyInez RamakersPhilip ScheltensCharlotte E TeunissenRik VandenbergheJolien SchaeverbekeSilvy GabelJulius PoppGwendoline PeyratoutPablo Martinez-LageMikel TaintaMagda TsolakiYvonne Freund-LeviSimon LovestoneJohannes StrefferFrederik BarkhofLars BertramKaj BlennowHenrik ZetterbergPieter Jelle VisserStephanie J B VosPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2022)
The pathophysiology of MCI-SNAP (A-T+) is distinct from that of MCI-AD. Our findings highlight the need for a different treatment in MCI-SNAP compared to MCI-AD.