Login / Signup

A model to predict anti-tuberculosis activity: value proposition for marine microorganisms.

Miaomiao LiuTanja GrkovicLixin ZhangXueting LiuRonald J Quinn
Published in: The Journal of antibiotics (2016)
The development of new antibiotics effective against all strains of tuberculosis (TB) is needed. To evaluate the potential of marine microbe-derived natural products as anti-TB leads, we analyzed and compared the physico-chemical properties of 39 current TB drugs and candidates against 60 confirmed mycobacteria-active natural products. We showed that anti-TB natural products sourced from marine microbes have a large overlap with TB drug-like space. A model to predict potential anti-TB drugs is proposed.
Keyphrases
  • mycobacterium tuberculosis
  • pulmonary tuberculosis
  • escherichia coli
  • hiv aids
  • hiv infected