Newly detected DNA viruses in juvenile nasopharyngeal angiofibroma (JNA) and oral and oropharyngeal squamous cell carcinoma (OSCC/OPSCC).

Amy Dickinson Man Xu Suvi RenkonenYilin WangYu FuMohammadreza SadeghiMari ToppinenTimo CarpénKlaus Hedman Antti Aarni Mäkitie Maria Söderlund Venermo

Published in: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery (2018)

These are the first reports of MCPyV and B19V DNA being detected in JNA and OPSCC. The significance of viral DNA positivity is unclear. B19V DNA is known to remain in the tissues lifelong, however, it is of interest that there are some patients with B19 DNA in healthy tissue, but not in the corresponding cancer tissue.

Keyphrases

circulating tumor
cell free
single molecule
squamous cell carcinoma
nucleic acid
sars cov
circulating tumor cells
gene expression
emergency department
young adults
locally advanced
drug induced