Polybrominated diphenyl ethers isolated from the marine sponge Lendenfeldia chondrodes collected in Mayotte.
Charifat Saïd HassaneFlorent TintillierPierre-Eric CamposGaëtan HerbetteNicole Joy de VoogdJamal OuazzaniMireille FouillaudLaurent DufosséAnne Gauvin-BialeckiPublished in: Natural product research (2023)
CDK7 and FynB protein kinases have been recognized as relevant targets for cancer and brain diseases treatment due to their pivotal regulatory roles in cellular functions such as cell cycle and neural signal transduction. Several studies demonstrated that the inhibition of these proteins could be useful in altering the onset or progression of these diseases. Based on bioassay-guided approach, the extract of the marine sponge Lendenfeldia chondrodes (Thorectidae), which exhibited interesting kinase inhibitory activities, was fractionated. The investigation led to the isolation of five known 1 - 5 and one new 6 polybrominated diphenyl ethers (PBDEs). Their structure elucidation was established based on spectroscopic data (NMR and HRMS) and comparison with literature data.
Keyphrases
- cell cycle
- cell proliferation
- electronic health record
- systematic review
- big data
- papillary thyroid
- magnetic resonance
- oxidative stress
- molecular docking
- high resolution
- squamous cell carcinoma
- resting state
- tyrosine kinase
- small molecule
- small cell lung cancer
- mass spectrometry
- multiple sclerosis
- binding protein
- blood brain barrier
- gas chromatography
- liquid chromatography
- brain metastases