White matter changes in primary central nervous system lymphoma patients treated with high-dose methotrexate with or without rituximab.

Fayez EstephanXiaobu YeOmar DzayeNina Wagner-JohnstonLode SwinnenDouglas E GladstoneRich AmbinderDavid Olayinka KamsonSebastian LambrechtStuart A GrossmanDoris D M LinMatthias Holdhoff

Published in: Journal of neuro-oncology (2019)

Development of WMC in PCNSL patients treated with MTX and MTX-R is common. WMC changes appear to be more frequent, occur earlier and are more extensive in patients treated with HD-MTX-R compared to HD-MTX. Prospective studies are required to determine whether WMC correlate with survival or neurocognitive outcomes.

Keyphrases

high dose
white matter
diffuse large b cell lymphoma
low dose
stem cell transplantation
bipolar disorder
multiple sclerosis
metabolic syndrome
type diabetes
hodgkin lymphoma
adipose tissue
case control
weight loss
insulin resistance