Linking specific biological signatures to different childhood adversities: findings from the HERO project.
Euclides José de Mendonça FilhoIrina PokhvisnevaChristina Maria MaaloufCarine ParentShanna B MlinerNatalie SlopenDavid R WilliamsNicole R BushWilliam Thomas BoycePat LevittCharles A NelsonMegan R GunnarMichael J MeaneyJack P ShonkoffPatricia Pelufo Silveiranull nullPublished in: Pediatric research (2023)
Different forms of early-life adversity have varied stress signatures, and investigations of early-life adversities with inflammation and HPA markers are lacking. Children with higher socioeconomic disadvantage had higher TNF-α, IL-1β, and DHEA. Higher family dysfunction was associated with higher hair cortisol and cortisone levels, and the association between family dysfunction and cortisol was moderated by socioeconomic disadvantage. Biological response systems (immune and endocrine) were differentially associated with distinct forms of early-life adversities.