Coronary vasospasm during infusion of CD-19 directed chimeric antigen receptor T-cell therapy: a case report.
Jacqueline J TaoNatalia RoszkowskaDavid T MajureSyed S MahmoodPublished in: European heart journal. Case reports (2023)
Given the complete resolution of symptoms and EKG abnormalities in the context of non-obstructive coronary artery disease, this clinical presentation was thought to be most consistent with ST elevation MI due to coronary vasospasm. The mechanism of this vasospasm is as yet not understood and may be related to an anaphylactic reaction or a cardiotoxicity related to the cell therapy agent. As the use of CAR-T therapy continues to expand, there is a need to further characterize the full spectrum of its cardiotoxic effects.
Keyphrases
- cell therapy
- coronary artery disease
- subarachnoid hemorrhage
- stem cells
- mesenchymal stem cells
- coronary artery
- brain injury
- cerebral ischemia
- cardiovascular events
- percutaneous coronary intervention
- low dose
- coronary artery bypass grafting
- heart failure
- physical activity
- transcatheter aortic valve replacement
- drug induced
- ejection fraction
- smoking cessation