Low-Income Older Adults' Vulnerability to Anticholinergic Medication-Associated Frailty.
Lana SargentKristin M ZimmermanAlmutairi MohammedMatthew J BarrettHuma NawazKathryn Wyman-ChickMarissa MackiewiczYoussef RomanPatricia SlattumSally RussellDave L DixonSarah K LagemanSarah HobgoodLeroy R ThackerElvin T PricePublished in: Drugs & aging (2023)
Anticholinergic burden tools evaluated in this cohort of low-income African American older adults were highly correlated and predicted prefrail and frail status. Findings indicate that clinicians can select the appropriate instrument for the clinic setting and research question while maintaining confidence that all five tools will produce reliable results. Future anticholinergic research is needed to unravel the association between interventions such as deprescribing on incident frailty in longitudinal data.