Risk factors and outcomes of neonates with acute kidney injury needing peritoneal dialysis: Results from the prospective TINKER (The Indian PCRRT-ICONIC Neonatal Kidney Educational Registry) study.
Sidharth Kumar SethiSanjay WazirJagdish SahooGopal AgrawalNaveen BajajNaveen Parkash GuptaShishir MirgundeBinesh BalachandranKamran AfzalAnubha ShrivastavaJyoti BaglaSushma KrishnegowdaAnanth KonapurAzmeri SultanaKritika SoniNikhil NairDivya SharmaPrajit KhooblallAvisha PandeyKhalid AlhasanMignon I McCullochTimothy BunchmanAbhishek TibrewalRupesh RainaPublished in: Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis (2022)
This is the largest prospective, multicentre study specifically looking at neonatal AKI and need for dialysis in neonates. AKI was seen in 30.7% of neonates (with the need for acute PD in 9% of the AKI group). The odds of needing acute PD were significantly higher among those with significant cardiac disease, inotropes usage, severe peripartum event, requirement of respiratory support in NICU, necrotising enterocolitis, any grade of intraventricular haemorrhage, evidence of fluid overload more than 10% during the first 12 h in NICU and requirement of resuscitation in the delivery room. AKI neonates with PD as compared to AKI neonates without PD had a significantly higher mortality. There is a need to keep a vigilant watch in neonates with risk factors for the development of AKI and need for PD.
Keyphrases
- acute kidney injury
- low birth weight
- preterm infants
- cardiac surgery
- peritoneal dialysis
- end stage renal disease
- risk factors
- liver failure
- chronic kidney disease
- preterm birth
- cardiac arrest
- respiratory failure
- type diabetes
- intensive care unit
- skeletal muscle
- insulin resistance
- hepatitis b virus
- mechanical ventilation