Transcriptomic alterations in hypertrophy of the ligamentum flavum: interactions of Rho GTPases, RTK, PIK3, and FGF.
Fernando Guevara-VillazónCesar Francisco Pacheco TenaAntonio Anchondo-LópezLuis Alberto Ordoñez-SolorioBenjamín Contreras MartínezArturo Muñoz-CobosArturo Luévano-GonzálezSusana Aideé González-ChávezPublished in: European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society (2023)
Our results suggest that abnormal processes in hypertrophied LF are mediated by the interaction of the Rho GTPase, RTK, and PI3K pathways, which have not been previously described in the HLF, but for which there are currently therapeutic proposals. More studies are required to confirm the therapeutic potential of the pathways and mediators described in our results.