The regio-selective synthesis of 10-hydroxy camptothecin norcantharidin conjugates and their biological activity evaluation in vitro.
Changkuo ZhaoChan LiXian H WangYu J BaoFu H YangMei HuangPublished in: Royal Society open science (2018)
A series of conjugates of 10-hydroxy camptothecin (HCPT) with functionalized norcantharidin derivatives were regio-selectively synthesized in the condition of (3-dimethylaminopropyl) ethyl-carbodiimide monohydrochloride in a moderate yield. The synthesized conjugate HCPT pro-drugs can also suppress cancer cell growth in vitro. These conjugated pro-drug constructs possess therapeutic potential as novel bi-functional conjugate platforms for cancer treatment.
Keyphrases
- cancer therapy
- anti inflammatory
- papillary thyroid
- drug delivery
- squamous cell
- photodynamic therapy
- high intensity
- quantum dots
- oxide nanoparticles
- drug induced
- squamous cell carcinoma
- childhood cancer
- emergency department
- molecularly imprinted
- young adults
- adverse drug
- structure activity relationship
- mass spectrometry
- solid phase extraction