SAR228810: an antibody for protofibrillar amyloid β peptide designed to reduce the risk of amyloid-related imaging abnormalities (ARIA).

Laurent PradierVéronique Blanchard-BrégeonAndrees BohmeThomas DebeirJean MenagerPatrick BenoitPascal BarneoudVéronique TaupinPhilippe BertrandPhilippe DugayBéatrice CameronYi ShiSouad NaimiMarc DuchesneMarie GagnaireTim WeedenTara TravalineDavid ReczekLeonard KhirougMohamed SlaouiPascale BrunelHidehiro FukuyamaJeffrey RavetchThierry CantonCaroline Cohen

Published in: Alzheimer's research & therapy (2018)

Based on the improved efficacy/safety profile in non-clinical models of SAR228810, a first-in-man single and multiple dose administration clinical study has been initiated in AD patients.

Keyphrases

end stage renal disease
newly diagnosed
chronic kidney disease
high resolution
peritoneal dialysis
mass spectrometry