Improvement of ACK1-targeted therapy efficacy in lung adenocarcinoma using chloroquine or bafilomycin A1.

Jinhong ZhuKui CaoMeng ZhaoKeru MaXiangyu JiangYuwen BaiXiaodong LingJianqun Ma

Published in: Molecular medicine (Cambridge, Mass.) (2023)

The resulting signature from ACK1-related autophagy genes robustly predicted survival and drug sensitivity in LUAD. The lysosomal degradation inhibition improved the therapeutic effects of the ACK1 inhibitor, suggesting a potential role for autophagy in therapy evasion.

Keyphrases

cell death
endoplasmic reticulum stress
signaling pathway
oxidative stress
genome wide
stem cells
drug induced
adverse drug
gene expression
free survival
mesenchymal stem cells
transcription factor
electronic health record