Development of the pupillary light reflex from 9 to 24 months: association with common autism spectrum disorder (ASD) genetic liability and 3-year ASD diagnosis.

Laurel A Fish Pär Nyström Teodora Gliga Anna Gui Jannath Begum AliLuke MasonShruti Garg Jonathan Michael Green Mark H Johnson Tony CharmanRebecca HarrisonEmma L Meaburn Terje Falck-Ytter Emily J H Jonesnull null

Published in: Journal of child psychology and psychiatry, and allied disciplines (2021)

These findings corroborate PLR development as possible intermediate phenotypes being linked to both genetic liability and phenotypic outcomes. Future work should incorporate alternative measures (e.g. functionally informed structural and genetic measures) to test whether distinct neural mechanisms underpin PLR alterations.

Keyphrases

autism spectrum disorder
attention deficit hyperactivity disorder
genome wide
intellectual disability
copy number
type diabetes
dna methylation
gene expression
skeletal muscle
weight loss