Absence in CX3CR1 receptor signaling promotes post-ischemic stroke cognitive function recovery through suppressed microglial pyroptosis in mice.

Yangyang GeJuexi YangJiayi ChenMaosha DaiXiaoke DouShanglong YaoChenye YaoYun Lin

Published in: CNS neuroscience & therapeutics (2024)

Our study demonstrated that CX3CR1 gene deletion was beneficial to PSCI recovery. The mechanism might lie in inhibited pyroptosis and enhanced neurogenesis. CX3CR1 receptor may serve as a therapeutic target for improving the PSCI.

Keyphrases

nlrp inflammasome
atrial fibrillation
inflammatory response
genome wide
lipopolysaccharide induced
high fat diet induced
type diabetes
neuropathic pain
adipose tissue
dna methylation
metabolic syndrome
gene expression
blood brain barrier
transcription factor
genome wide analysis
wild type