Login / Signup

Subcutaneous checkpoint inhibition is equivalent to systemic delivery when combined with nelitolimod delivered via pressure-enabled drug delivery for depletion of intrahepatic myeloid-derived suppressor cells and control of liver metastases.

Chandra C GhoshLauren CournoyerYujia LiuAlizee BallarinIlan B LaymanJason LaPorteMolly MorrisseyKayla FraserShriya PeratiBryan F CoxEvgeny YakirevichDiana O TreabaTimothy D MurthaPrajna GuhaSteven C KatzDiwakar Davar
Published in: Journal for immunotherapy of cancer (2024)
The SQ route of CPI delivery was equivalent to Sys in combination with nelitolimod, suggesting SQ-CPI may be a rational choice in combination with PEDD of nelitolimod for liver tumor treatment.
Keyphrases
  • liver metastases
  • drug delivery
  • induced apoptosis
  • dna damage
  • cell cycle arrest
  • cell cycle
  • cancer therapy
  • oxidative stress
  • combination therapy
  • cell death
  • signaling pathway
  • drug induced