DNA Damage and Nuclear Morphological Changes in Cardiac Hypertrophy Are Mediated by SNRK Through Actin Depolymerization.
Paulina StanczykYuki TatekoshiJason S ShapiroKrithika NayuduYihan ChenZachary A ZilberMatthew John SchipmaAdam De JesusAmir MahmoodzadehAshley AkramiHsiang-Chun ChangHossein ArdehaliPublished in: Circulation (2023)
These results indicate that SNRK is a key player in cardiac hypertrophy and DNA damage through its interaction with DSTN. This interaction fine-tunes actin polymerization to reduce DDR and maintain proper cardiomyocyte nuclear shape and morphology.