Immunogenic hypofractionated radiotherapy sensitising head and neck squamous cell carcinoma to anti-PD-L1 therapy in MDSC-dependent manner.

Liang MaoJun-Jie ZhouYao XiaoQi-Chao YangShao-Chen YangShuo WangZhi-Zhong WuHong-Gang XiongHai-Jun Yu Zhi-Jun Sun

Published in: British journal of cancer (2023)

These results present a translatable method to substantially improve the antitumor immune response by combining PD-L1 blockade with immunogenic hypofractionated radiotherapy in HNSCC.

Keyphrases

radiation therapy
immune response
locally advanced
early stage
radiation induced
squamous cell carcinoma
brain metastases
stem cells
dendritic cells
toll like receptor
small cell lung cancer