Investigations into the Signaling Pathways Involving Glucose-Stimulated Zinc Secretion (GSZS) from Prostate Epithelial Cells In Vitro and In Vivo.

Daniel ParrottEul Hyun SuhPooyan KhalighinejadVeronica Clavijo JordanIvan ArreolaSu-Tang LoA Dean Sherry

Published in: Molecular imaging and biology (2023)

GSZS requires metabolism of glucose both in vitro (PNT1A cells) and in vivo (rat prostate). Pyruvate also stimulates zinc secretion in vivo but likely via an indirect pathway involving rapid production of glucose via gluconeogenesis. These combined results support the conclusion that glycolytic flux is required to trigger GSZS in vivo.

Keyphrases

prostate cancer
blood glucose
induced apoptosis
signaling pathway
benign prostatic hyperplasia
oxide nanoparticles
cell cycle arrest
oxidative stress
skeletal muscle
adipose tissue
metabolic syndrome
endoplasmic reticulum stress
epithelial mesenchymal transition