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Radiation-induced toxicity in rectal epithelial stem cell contributes to acute radiation injury in rectum.

Felipe Rodriguez TiradoPayel BhanjaEduardo Castro-NallarXimena Diaz OleaCatalina SalamancaSubhrajit Saha
Published in: Stem cell research & therapy (2021)
Lgr5-positive rectal stem cells are radiosensitive and contribute to radiation-induced rectal epithelial toxicity. Transplantation of Lgr5-positive rectal stem cells mitigates radiation-induced rectal injury and promotes repair and regeneration process in rectum.
Keyphrases
  • radiation induced
  • stem cells
  • radiation therapy
  • rectal cancer
  • cell therapy
  • oxidative stress
  • liver failure
  • drug induced
  • aortic dissection