Extended exome sequencing identifies BACH2 as a novel major risk locus for Addison's disease.
Daniel ErikssonM BianchiN LandegrenJ NordinF DalinA MathioudakiG N ErikssonL Hultin-RosenbergJ DahlqvistH ZetterqvistÅ KarlssonÅ HallgrenF H G FariasE MurénK M AhlgrenA LobellG AnderssonK TandreS R DahlqvistP SöderkvistL RönnblomA-L HultingJ WahlbergO EkwallP DahlqvistJ R S MeadowsS BensingK Lindblad-TohO KämpeG R PielbergPublished in: Journal of internal medicine (2016)
Whilst BACH2 has been previously reported to associate with organ-specific autoimmune diseases co-inherited with Addison's disease, we have identified BACH2 as a major risk locus in Addison's disease, independent of concomitant autoimmune diseases. Our results may enable future research towards preventive disease treatment.
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