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Deficiency in hormone-sensitive lipase accelerates the development of pancreatic cancer in conditional KrasG12D mice.

Mu XuHui-Hua ChangXiaoman JungAune MoroCaroline Ei Ne ChouJonathan KingO Joe HinesJames Sinnett-SmithEnrique RozengurtGuido Eibl
Published in: BMC cancer (2018)
HSL deficiency is associated with adipose tissue and pancreatic inflammation and accelerates PDAC development in the KC mouse model.
Keyphrases
  • adipose tissue
  • mouse model
  • oxidative stress
  • insulin resistance
  • replacement therapy
  • high fat diet
  • high fat diet induced