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Diagnostic MR imaging features of hypomyelination of early myelinating structures: A case report.

Tokiko AbeKoji YamashitaKazufumi KikuchiEriko HataiFumihiko FujiiPin Fee ChongYasunari SakaiHirotomo SaitsuKen InoueOsamu TogaoKousei Ishigami
Published in: The neuroradiology journal (2023)
Hypomyelination of early myelinating structures (HEMS) has recently been defined as a new genetic disorder accompanied by clinical and MR imaging characteristics. However, no studies have focused on diffusion-weighted imaging (DWI) findings of HEMS. We would like to propose a "sheep sign," which is formed by DWI hyperintensity in the medial medullary lamina along with alternating high-low-high (HLH) intensity stripes in the posterior limb of the internal capsule. We believe the presence of the "sheep sign" on DWI in combination with alternating HLH intensity stripes may be a valuable tool for diagnosing HEMS.
Keyphrases
  • diffusion weighted imaging
  • contrast enhanced
  • magnetic resonance imaging
  • diffusion weighted
  • magnetic resonance
  • computed tomography
  • high intensity
  • high resolution
  • copy number
  • case control