HIV-infection and cocaine use regulate semen extracellular vesicles proteome and miRNAome in a manner that mediates strategic monocyte haptotaxis governed by miR-128 network.
Hussein KaddourSteven KopchoYuan LyuNadia ShoumanVictor ParomovSiddharth PratapChandravanu DashEun-Young KimJeremy MartinsonHeather McKayMarta EpeldeguiJoseph B MargolickJack T StapletonChioma M OkeomaPublished in: Cellular and molecular life sciences : CMLS (2021)
We propose that compositionally and functionally distinct HIV + COC + and HIV-COC- SEVs and their exmiR networks may provide cells relevant but divergent haptotactic guidance in the absence of chemotactic cues, under both physiological and pathophysiological conditions.
Keyphrases
- antiretroviral therapy
- hiv infected
- hiv positive
- human immunodeficiency virus
- hiv testing
- hiv aids
- hepatitis c virus
- induced apoptosis
- men who have sex with men
- cell proliferation
- long non coding rna
- cell cycle arrest
- dendritic cells
- south africa
- endothelial cells
- endoplasmic reticulum stress
- signaling pathway
- prefrontal cortex