A multiorganism pipeline for antiseizure drug discovery: Identification of chlorothymol as a novel γ-aminobutyric acidergic anticonvulsant.
Alistair JonesMelissa Barker-HaliskiAndrei S IlieMurray B HerdSarah BaxendaleCelia J HoldsworthJohn-Paul AshtonMarysia PlaczekBodiabaduge A P JayasekeraChristopher J A CowieJeremy J LambertAndrew J TrevelyanH Steve WhiteAnthony G MarsonVincent T CunliffeGraeme J SillsAlan MorganPublished in: Epilepsia (2020)
These findings establish a multiorganism approach that can identify compounds with evolutionarily conserved molecular targets and translational potential, and so may be useful in drug discovery for epilepsy and possibly other conditions.