Prevalence and effect of pre-treatment drug resistance on the virological response to antiretroviral treatment initiated in HIV-infected children - a EuroCoord-CHAIN-EPPICC joint project.
Nicole Ngo-Giang-HuongLinda WittkopAli JuddPeter ReissTessa GoetghebuerDan DuiculescuAntoni Noguera-JulianMagdalena MarczynskaCarlo GiacquintoLuminita EneJose T RamosCristina CelleraiThomas KlimkaitBenedicte BrichardNiels ValeriusCaroline SabinRamon TeiraNiels ObelChristoph StephanStéphane de WitClaire ThorneDiana GibbChristine SchwimmerMaria Athena CampbellDeenan PillayMarc Lallemantnull nullPublished in: BMC infectious diseases (2016)
PDR was not significantly associated with a higher risk of VF in children in the first year of cART. The risk of VF decreased by 12 % per additional year at treatment initiation which may be due to fading of PDR mutations over time. Lack of appropriate formulations, in particular for the younger age group, may be an important determinant of virological failure.