DNA Cleavage by Chemically Exfoliated Molybdenum Disulfide Nanosheets.
Yingcan ZhaoJiayi XuXingyu JiangPublished in: Environmental science & technology (2021)
Chemically exfoliated MoS2 (ce-MoS2) nanosheets have been widely used in biomedical and environmental fields. Some in vitro studies demonstrated that ce-MoS2 might induce toxicity. However, the understanding of the mechanism of potential toxicity is lacking. In this study, we found that ce-MoS2 could directly induce breakage of double-stranded DNA with or without an external energy input, making it different from other two-dimensional nanomaterials. In a dark environment, the DNA cleavage exhibited a pH-dependent trend due to reactive oxygen species generation under different pH values. Under photoirradiation, DNA cleavage could be enhanced. This study provides insights into the potential environmental risk and toxicity of ce-MoS2 in the aquatic environment.
Keyphrases
- quantum dots
- reduced graphene oxide
- circulating tumor
- cell free
- transition metal
- room temperature
- single molecule
- highly efficient
- energy transfer
- human health
- oxidative stress
- reactive oxygen species
- nucleic acid
- risk assessment
- dna binding
- gold nanoparticles
- circulating tumor cells
- transcription factor
- binding protein
- oxide nanoparticles