Measuring the Effect of Cutaneous Neurofibromas on Quality of Life in Neurofibromatosis Type 1.
Sheilagh M MaguinessYemima D BermanNathan RubinMelissa DoddsScott R PlotkinClaire WongChristopher L Moertelnull nullPublished in: Neurology (2021)
The development of cNF in adolescence and adulthood in NF1 often leads to progressive disfigurement and discomfort and is among one of the most common reasons for patients to seek medical treatment. Skindex has been used to assess skin-related quality of life in NF1 previously but is not specific to NF1. These findings highlight the need for a low threshold for referral to dermatologists for all patients with NF1 regardless of the severity of disease. The finding that facial cNF and higher total number of cNF correlates with poorer skin-related quality of life may benefit design of more specific NF1 skin-related quality of life measures.
Keyphrases
- signaling pathway
- lps induced
- pi k akt
- nuclear factor
- oxidative stress
- soft tissue
- end stage renal disease
- depressive symptoms
- inflammatory response
- healthcare
- chronic kidney disease
- wound healing
- ejection fraction
- primary care
- multiple sclerosis
- peritoneal dialysis
- prognostic factors
- immune response
- patient reported