Transthyretin Amyloid Cardiomyopathy: Impact of Transthyretin Amyloid Deposition in Myocardium on Cardiac Morphology and Function.

Tomoya NakanoKenji OnoueChiyoko TeradaSatoshi TerasakiSatomi IshiharaYukihiro HashimotoYasuki NakadaHitoshi Nakagawa Tomoya UedaAyako SenoTaku NishidaMakoto WatanabeYoshinobu Hoshii Kinta HatyakeyamaYasuhiro SakaguchiChiho OhbayashiYoshihiko Saito

Published in: Journal of personalized medicine (2022)

Patients with ATTR-CM mainly displayed concentric LVH geometry. TTR amyloid deposition was associated with cardiac dysfunction via increased non-cardiomyocyte area and ROS accumulation in cardiomyocytes.

Keyphrases

left ventricular
heart failure
oxidative stress
cell death
wild type
dna damage
high glucose