Temporal control of protein labeling by a photo-caged benzaldehyde motif and discovery of host cell factors of avian influenza virus infection.

Nicholas L AsiimweJung Hoon LeeKyung Tae HongDhiraj P MuraleMd Mamunul HaqueDong-Hoon KimJun-Seok Lee

Published in: Chemical communications (Cambridge, England) (2022)

Photo-caged benzaldehyde probes using o -nitrophenylethylene glycol were designed for photo-activated electrophile generation. Using photo-activated electrophile generating probes, we successfully revealed under-represented host cell response factors using an avian influenza virus infection model.

Keyphrases

single cell
small molecule
cell therapy
electron transfer
single molecule
living cells
high throughput
fluorescence imaging
protein protein
photodynamic therapy
fluorescent probe