Irf4-dependent CD103+CD11b+ dendritic cells and the intestinal microbiome regulate monocyte and macrophage activation and intestinal peristalsis in postoperative ileus.
Judith-Mira PohlSebastian GutweilerStephanie ThiebesJulia K VolkeLudger Klein-HitpassDenise ZwanzigerMatthias GunzerSteffen JungWilliam W AgaceChristian KurtsDaniel Robert EngelPublished in: Gut (2017)
Our findings reveal that CD103+CD11b+ DCs and the intestinal microbiome are a prerequisite for the activation of intestinal monocytes and macrophages and for dysregulating intestinal motility in POI.