Maternal dietary glycaemic change during gestation influences insulin-related gene methylation in the placental tissue: a genome-wide methylation analysis.
Wei-Li YanYi ZhangLiping WangWenhong YangChunying LiLiling WangPing GuYingqian XiaJuhua YanYing ShenQian ZhaoDayan NiuKai MuYuan JiangPublished in: Genes & nutrition (2019)
We provide the first evidence that maternal dietary GI changes during gestation may impact placental DNA methylation of insulin regulation genes. This supports the hypothesis that placental methylation may be the epigenetic mechanism through which maternal diet influences the metabolic health of offspring.
Keyphrases
- genome wide
- dna methylation
- type diabetes
- birth weight
- gestational age
- copy number
- gene expression
- pregnancy outcomes
- preterm infants
- glycemic control
- public health
- mental health
- weight loss
- body mass index
- pregnant women
- preterm birth
- skeletal muscle
- adipose tissue
- insulin resistance
- climate change
- metabolic syndrome
- health information
- genome wide identification