Catalytic Generation and Chemoselective Transfer of Nucleophilic Hydrides from Dihydrogen.

Felix PapeLea T BrechmannJohannes F Teichert

Published in: Chemistry (Weinheim an der Bergstrasse, Germany) (2018)

Copper(I)-N-heterocyclic-carbene (NHC) complexes enabled the catalytic generation of nucleophilic hydrides from dihydrogen (H2 ) and their subsequent transfer to allylic chlorides. The highly chemoselective catalyst displayed no concomitant hydrogenation reactivity; in fact, the terminal double bond formed in the hydride transfer remained intact. Switching to deuterium gas (D2 ) allowed for regioselective monodeuteration with excellent isotope incorporation.

Keyphrases

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