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Iron-Based Metal-Organic Frameworks in Drug Delivery and Biomedicine.

Xianbin LiuTiantian LiangRongtao ZhangQian DingSiqiong WuChunhong LiYan LinYun YeZhirong ZhongMeiling Zhou
Published in: ACS applied materials & interfaces (2021)
Metal-organic frameworks (MOFs) are crystalline materials comprising metal centers and organic linkers that feature structural rigidity and functional flexibility. These attractive materials offer large surface areas, high porosity, and good chemical stability; they have shown promise in chemistry (H2 separation and catalysis), magnetism, and optics. They have also shown potential for drug delivery following the demonstration in 2006 that chromium-based MOFs can be loaded with ibuprofen. Since then, iron-based MOFs (Fe-MOFs) have been shown to offer high drug loading and excellent biocompatibility. The present review focuses on the synthesis and surface modifications of Fe-MOFs as well as their applications in drug delivery and biomedicine.
Keyphrases
  • metal organic framework
  • drug delivery
  • cancer therapy
  • drug release
  • machine learning
  • emergency department
  • big data
  • risk assessment
  • climate change
  • deep learning
  • ionic liquid
  • adverse drug