Avenanthramide and β-Glucan Therapeutics Accelerate Wound Healing via Distinct and Nonoverlapping Mechanisms.

AVN and β-Glucan accelerated wound closure compared to controls through distinct mechanisms. AVN treated scars displayed a more regenerative tissue architecture with reduced inflammatory cell recruitment, while β-Glucan demonstrated increased angiogenesis with more highly aligned tissue architecture more indicative of fibrosis. A deeper understanding of the mechanisms driving healing in these two naturally derived therapeutics will be important for translation to human use.  .