Exploring Causal Relationships between Circulating Inflammatory Proteins and Thromboangiitis Obliterans: A Mendelian Randomization Study.

Bihui ZhangRui HeZiping YaoPengyu LiGuochen NiuZiguang YanYinghua ZouXiaoqiang TongMin Yang

Published in: Thrombosis and haemostasis (2024)

This study identifies C-C motif chemokine 4 and glial cell line-derived neurotrophic factor as potential protective biomarkers for TAO, whereas C-C motif chemokine 23 emerges as a suggestive risk marker. These findings elucidate potential causal relationships and highlight the significance of these proteins in the pathogenesis and prospective therapeutic strategies for TAO.

Keyphrases

oxidative stress
genome wide
risk assessment
spinal cord
human health
dna methylation