Seizure characteristics and outcomes in patients with neurological conditions related to high-risk paraneoplastic antibodies.
Kelsey M SmithJeffrey W BrittonSmathorn ThakolwiboonNicholas H ChiaPranjal GuptaEoin P FlanaganAnastasia ZekeridouAlfonso S Sebastian Lopez ChiribogaCristina Valencia SanchezAndrew McKeonSean J PittockDivyanshu DubeyPublished in: Epilepsia (2023)
Seizures in the setting of high-risk paraneoplastic antibodies are frequently resistant to treatment. Ongoing seizures are associated with ANNA1-IgG and Ma2-IgG, high seizure frequency, and EEG and imaging abnormalities. While a subset of patients may respond to immunotherapy and achieve seizure freedom, poor outcomes are frequently encountered. Death was more common among patients with LE.
Keyphrases
- temporal lobe epilepsy
- end stage renal disease
- chronic kidney disease
- ejection fraction
- newly diagnosed
- high resolution
- peritoneal dialysis
- working memory
- adipose tissue
- patient reported outcomes
- functional connectivity
- resting state
- metabolic syndrome
- skeletal muscle
- combination therapy
- glycemic control
- replacement therapy
- smoking cessation