Formicins, N-Acetylcysteamine-Bearing Indenone Thioesters from a Wood Ant-Associated Bacterium.

Young Eun DuWoong Sub ByunSeok Beom LeeSunghoon HwangYern-Hyerk ShinBora ShinYong-Joon JangSuckchang HongJongheon Shin Sang-Kook Lee Dong-Chan Oh

Published in: Organic letters (2020)

Formicins A-C (1-3) were discovered from Streptomyces sp. associated with wood ants. The structures of 1 and 2 were elucidated as indenone thioesters bearing N-acetylcysteamine based on spectroscopic analysis. The configurations of 1-3 were determined by the analysis of ROESY correlations, the phenylglycine methyl ester method, and chemical derivatization from 3 to 2. Formicin A inhibited the growth of human triple-negative breast cancer cells by regulating the liver kinase B1-mediated AMPK signaling pathway.

Keyphrases

breast cancer cells
signaling pathway
endothelial cells
protein kinase
ms ms
molecular docking
pi k akt
skeletal muscle
high resolution
epithelial mesenchymal transition
cell wall
gas chromatography mass spectrometry
tyrosine kinase
cell proliferation
molecular dynamics simulations