Kras and Lkb1 mutations synergistically induce intraductal papillary mucinous neoplasm derived from pancreatic duct cells.

Louis ColletElsa GhurburrunNora MeyersMohamad AssiBoris PirlotIsabelle A LeclercqAnne CouvelardMina KomutaJérôme CrosPieter DemetterFrédéric P LemaigreIvan BorbathPatrick Jacquemin

Published in: Gut (2019)

Our work demonstrates that IPMN can result from synergy between Kras G12D mutation and inactivation of a tumour suppressor gene. The ductal epithelium can give rise to glandular neoplasms and papillary lesions, which probably both contribute to IPMN formation.

Keyphrases

low grade
induced apoptosis
wild type
clear cell
cell cycle arrest
genome wide
copy number
signaling pathway
high grade
gene expression
genome wide identification
pi k akt