Nucleophilic Ring Opening of Donor-Acceptor Cyclopropanes with the Cyanate Ion: Access to Spiro[pyrrolidone-3,3'-oxindoles].
Sergey V ZaytsevKonstantin L IvanovDmitry A SkvortsovStanislav I BezzubovMikhail Ya MelnikovEkaterina M BudyninaPublished in: The Journal of organic chemistry (2018)
The nucleophilic ring opening of donor-acceptor cyclopropanes with the cyanate ion is reported for the first time. Cyclopropanes, spiro-activated with oxindole fragments as acceptors, are shown to undergo transformations into biologically relevant spiro[pyrrolidone-3,3'-oxindoles] while being treated with potassium cyanate under microwave assistance.