Large-Scale Synthesis of Functionalized Nanowires to Construct Nanoelectrodes for Intracellular Sensing.
Wen-Tao WuHong JiangYu-Ting QiWen-Ting FanJing YanYan-Ling LiuWei-Hua HuangPublished in: Angewandte Chemie (International ed. in English) (2021)
A strategy for one-pot and large-scale synthesis of functionalized core-shell nanowires (NWs) to high-efficiently construct single nanowire electrodes is proposed. Based on the polymerization reaction between 3,4-ethylenedioxythiophene (EDOT) and noble metal cations, manifold noble metal nanoparticles-polyEDOT (PEDOT) nanocomposites can be uniformly modified on the surface of any nonconductive NWs. This provides a facile and versatile approach to produce massive number of core-shell NWs with excellent conductivity, adjustable size, and well-designed properties. Nanoelectrodes manufactured with such core-shell NWs exhibit excellent electrochemical performance and mechanical stability as well as favorable antifouling properties, which are demonstrated by in situ intracellular monitoring of biological molecules (nitric oxide) and unraveling its relevant unclear signaling pathway inside single living cells.
Keyphrases
- reduced graphene oxide
- living cells
- gold nanoparticles
- room temperature
- nitric oxide
- fluorescent probe
- quantum dots
- signaling pathway
- ionic liquid
- molecularly imprinted
- reactive oxygen species
- single molecule
- pi k akt
- nitric oxide synthase
- epithelial mesenchymal transition
- carbon nanotubes
- hydrogen peroxide
- highly efficient
- mass spectrometry
- induced apoptosis
- solid phase extraction
- perovskite solar cells