Mycobacterium africanum (Lineage 6) shows slower sputum smear conversion on tuberculosis treatment than Mycobacterium tuberculosis (Lineage 4) in Bamako, Mali.

Bassirou DiarraMahamadou KoneAntieme Combo Georges TogoYeya Dit Sadio SarroAissata Boubakar CisseAmadou SomboroBoureima DegogaMohamed TolofoudieBourahima KoneMoumine SanogoBocar BayaOusmane KodioMamoudou MaigaMichael BelsonSusan OrsegaMeryam KritSounkalo DaoIbrahim Izétiegouma MaigaRobert L MurphyLeen RigoutsSeydou DoumbiaSouleymane DialloBouke Catherine de Jong

Published in: PloS one (2018)

The six major human lineages of the MTBc all circulate in Bamako. Counter to our hypothesis, we found that patients diseased with modern M. tuberculosis complex L4 respond faster to TB treatment than those with M. africanum L6.

Keyphrases

mycobacterium tuberculosis
pulmonary tuberculosis
end stage renal disease
endothelial cells
chronic kidney disease
cystic fibrosis
single cell
peritoneal dialysis
combination therapy
patient reported outcomes
electronic health record
cell fate