Delaying an infliximab infusion by more than 3 days is associated with a significant reduction in trough levels but not with clinical worsening.

Zohar Ben ShatachTomer Ziv-BaranElla FudimMiri YavzoriOrit PicardAsaf LevartovskyLimor SelingerBatia WeissUri KopylovRami EliakimBella Ungar

Published in: Therapeutic advances in gastroenterology (2022)

A total of 2088 sera of 302 maintenance period inflammatory bowel disease (IBD) patients treated with infliximab were analyzed, to assess effect of small deviations from infusion schedule on TLs. A significant decline in patients' trough level (TL) was noted as early as 3 days after scheduled infusion.

Keyphrases

ulcerative colitis
low dose
end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
prognostic factors
patient reported outcomes