Genetic variation in NFE2L2 is associated with outcome following aneurysmal subarachnoid haemorrhage.
Ben GaastraPoppy DuncanMark K BakkerIsabel C HostettlerVarinder S AlgHenry HouldenYnte M RuigrokIan GaleaWill TapperDavid WerringDiederik BultersPublished in: European journal of neurology (2022)
The NFE2L2 SNP, rs10183914, is significantly associated with outcome following aSAH. This is consistent with a clinically relevant pathophysiological role for oxidative and inflammatory brain injury due to blood and its breakdown products in aSAH. Furthermore, our findings support NRF2 as a potential therapeutic target following aSAH and other forms of intracranial haemorrhage.