Single-Cell Profiling Indicates a Proinflammatory Role of Meningeal Ectopic Lymphoid Tissue in Experimental Autoimmune Encephalomyelitis.

Jolien DiddensGildas LepennetierVerena FriedrichMonika SchmidtRosa M BrandTanya GeorgievaBernhard Hemmer Klaus Lehmann-Horn

Published in: Neurology(R) neuroimmunology & neuroinflammation (2023)

Common features in immune cell composition and gene expression indicate that mELT resembles SLOs and may be regarded as a tertiary lymphoid tissue. Distinct differences in expression profiles suggest that mELT rather than SLOs is a key driver of CNS inflammation in spontaneous EAE. Our data provide a starting point for further exploration of molecules or pathways that could be targeted to disrupt mELT formation.

Keyphrases

single cell
gene expression
rna seq
oxidative stress
dna methylation
high throughput
cancer therapy
big data
drug delivery