MFAP4-Deficiency Aggravates Age-Induced Changes in Resistance Artery Structure, While Ameliorating Hypertension.

Kimmie B ChristensenŞeyda ÜnsalMorten Frendø EbbesenLine HemstraAnders SchlosserKristoffer RosenstandPernille B L HansenBoye L JensenMaria BloksgaardUlf Simonsen Grith Lykke Sorensen

Published in: Hypertension (Dallas, Tex. : 1979) (2024)

MFAP4-deficiency reduces the elastin/collagen ratio in the aging resistance artery without affecting arterial stiffness. In contrast, MFAP4-deficiency reduces the stiffness of resistance arteries and ameliorates Ang II-induced hypertension.

Keyphrases

blood pressure
magnetic resonance
magnetic resonance imaging
angiotensin ii
drug induced
arterial hypertension
stress induced