Hyperglucagonemia in Pediatric Adiposity Associates With Cardiometabolic Risk Factors but Not Hyperglycemia.

Sara Elizabeth StinsonAnna E JonssonIerai Fernández de Retana AlzolaMorten A V LundChristine Frithioff-BøjsøeLouise Aas HolmCilius E FonvigOluf PedersenLars ÄngquistThorkild I A SørensenJens J HolstMichael ChristiansenJens-Christian HolmBolette Hartmann Torben Hansen

Published in: The Journal of clinical endocrinology and metabolism (2022)

Compared with normal weight peers, children and adolescents with overweight/obesity had elevated concentrations of fasting glucagon, which corresponded to worsened cardiometabolic risk outcomes, except for hyperglycemia. This suggests hyperglucagonemia in youth may precede impairments in glucose regulation.

Keyphrases

weight gain
weight loss
insulin resistance
risk factors
physical activity
blood glucose
body mass index
glycemic control
metabolic syndrome
diabetic rats
adipose tissue
type diabetes
high fat diet induced
mental health
young adults
skeletal muscle
blood pressure
oxidative stress